Stem Cell Basics

 

ASCs

(Adipose-derived Stem Cells)


Why Use Fat as a Source of Stem Cells?

 

A set of ideal criteria for stem cells in regenerative medicine has been identified recently [Gimble 2003],

 

and the table below shows how well adipose tissue matches these criteria.

 

  


  Ideal Stem Cell Criteria      Fat comments                                                    
  1 Found in abundant quantities          

    yes

Increasing obesity worldwide

 
Liposuction procedures yield between 100 ml to > 3 liter

 
  2 Harvested via minimally invasive procedure     yes

Cryo-Lip procedure requires only 50 ml of lipoaspirate 

 

Patient friendly compared to bone marrow aspiration

 
  3 Can be differentiated in multiple cell lineages     yes Multiple cells have been grown from ASCs, including fat, bone, cartilage, muscle, neuron, pancreas  
  4 Can be safely and effectively transplanted     yes

Fat grafting is a well accepted in plastic surgery

 
Cryo-Lip is for adult and autologous use

(no immunology or ethical problems)

 
  5 Can be manufactured to GMP guidelines     yes Established in many laboratories  

 

In summary, ASCs as obtained in the Cryo-Lip procedure are a logical choice for clinical uses as they are:

 

        Abundantly available in adults
     
  Relatively easy to isolate and expand
     
  Autologous, hence no ethical or immunological problems 


 
    Trust
 
 > 120,000 samples stored